Common medicines accumulate in the intestinal bacteria making it difficult to treat
Cambridge: An important discovery has been made that although the common medicines for asthma, depression and diabetes have their effect, in the long run they accumulate in the intestinal bacteria and may further reduce the effect of many medicines. Or doing. This is because the accumulation of drugs causes the bacteria to change abnormally.
With this information we can understand the different effects of drugs on different people and their side effects. According to a report published in the weekly scientific journal Nature, some bacteria can chemically alter certain drugs called biotransformation.
Findings from the University of Cambridge and the European Molecular Biology Laboratory (EMBL), Germany, show that many common drugs slowly enter bacteria and not only change them internally but also change their function. It is now thought that bacterial mutations can directly affect new drugs and can directly alter the functions of bacteria, which can increase the side effects of the drug.
Our stomach, intestines and digestive system contain hundreds, thousands of types of bacteria that play an important role not only in health but also in diseases. This whole set is called the gut microbiome. The order varies from person to person, and now we have identified clusters of healthy bacteria. Their deterioration can lead to obesity, the immune system and mental illness.
In their research, the scientists identified 25 common bacteria and exposed them to 15 common medications. A total of 375 drugs and bacteria were tested. There were 70 matches in the study, 29 of which had never been seen before.
Thus, in 17 of the 29 new interactions between bacteria and drugs, the drug began to accumulate without change. Then, a drug for depression, dvoloxetine, changed the bacterial colony and severely damaged its balance. Then they were tested on an insect and after that the behavior of the insects also changed.
Experts believe this is a new chapter of research that needs further investigation.