Cellular time machine that reverses pancreatic cancer
New York: Pancreatic cancer is spreading at an alarming rate, but now it can be reversed with a cellular time machine.
The cellular time machine was developed by Professor Bamsu Han and colleagues at the University of Purdue Cancer Research Center. “Now, for the first time, we’ve figured out a way to heal cancer cells by turning the clock back on them, which could lead to new treatments and new drugs,” he said.
He first created a living model of the pancreas, which he named Aquinas. It sends digestive juices into the small intestine. In pancreatic cancer, inflammation first develops as a result of cellular mutations, and the pancreas itself begins to be affected by its own altered enzymes.
The researchers looked at the pancreatic cancer cells and asked them to make the earlier enzymes, and the cells began to recover. If the cells (cells) are free of cancer then the whole bubble can come out of the cancer by itself which we can call reset.
To make this impossible task, scientists have already worked on a cancer-resetting gene, PTF1A, which includes Professor Stephen Konizeni of the same institute. This gene is very important for the pancreas and it builds it. Now, if it is activated in the cancerous pancreas, the cancer can be removed.
The experts dug a hole in a microscopic slide and filled it with cells that were arranged in 3D in lines. Then a brand new technology called ‘viscous fingering’ was developed and then a line of cancer cells was made on the slide.
Now, when the PTF1A gene is reactivated in pancreatic cancer cells, the remaining cells on the slide are out of the cancerous state, that is, reprogrammed.
This breakthrough could open the door to gene therapy for the treatment of pancreatic cancer.